It will be interesting to see how design, particularly website design, evolves over the next ten years.
Couple of hopes/requests/wishlist items:
- Get CMS systems to play nicely with custom databases & custom applications
- Figure out way of unifying user login/accounts across multiple website applications
- Clean URLs system for customs sites
- Style Inheritance in CSS
- Death of IE6 and the end of IE6 CSS overrides
Should be an interesting decade for design!